游离PSA与总PSA比值在前列腺疾病诊断中的应用

Significance of F/T PSA Ratio in Diagnosis of Prostate Disease

目的 :探讨总前列腺特异性抗原 (T_PSA)、游离前列腺特异性抗原 (F_PSA)及F_PSA/T_PSA(F/T)比值的变化在良性与恶性前列腺疾病诊断及鉴别诊断中的应用价值。方法 :应用链霉亲和素生物素酶联免疫吸附试验 (SAB_ELISA)方法 ,检测50例前列腺增生 (BPH)、41例前列腺癌 (PCa)及11例前列腺炎患者血清T_PSA、F_PSA含量并计算F/T比值。结果 :F/T比值在前列腺增生和前列腺癌中有显著性差异(P<0.01) ,当T_PSA在4～10μg/L之间时 ,前列腺增生和前列腺癌患者中F/T比值呈现显著差异(P<0.01)。结论 :同时检测T_PSA和F_PSA ,计算F/T比值 ,可弥补在诊断前列腺疾病的传统检验中单纯测定T_PSA的不足 ,尤其对T_PSA在4～10μg/L之间的诊断“灰色区”

To discuss the significance of free/total prostate special antigen(F/T PSA)ratio in diagnosis of prostate disease.Methods:The concentrations of serum T_PSA and F_PSA were detected in 50 patients with benign prostate hyperplasia(BPH),41 patients with prostate cancer(PCa) and 11 patients with prostate inflammation by SAB_ELISA,and the ratio of F/T PSA was calculated.Results:When T_PSA was in the range of 4～10 μg/L,there was a significant difference in F/T ratio between BPH and PCa(P<0.01). Conclusion:Concomitantly detecting T_PSA and F_PSA can offset the limination of traditional diagnosis of prostate disease,especially when T_PSA is in the range of 4～10 μg/L.