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紫外-可见分光光度法对去甲柔红霉素电离常数的研究 被引量：5

Study of the Ionization Constant of Anticancer Drug-idabicin with UV-Vis
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摘要 作者用紫外-可见分光光度法(UV-Vis)研究了抗癌药物-去甲柔红霉素的电离常数。配制了一系列pH值的去甲柔红霉素溶液并在去甲柔红霉素的特征波长485nm处分别测定它们的吸光度,根据吸光度的变化求得去甲柔红霉素的pKa值。该方法简单、易行,操作方便。 In this paper, UV-Visible spectrometry was employed to study the ionization constant of anticancer-drug Idabicin. The standard solution of series pH value were prepared and the absorbance was measured at 485 nm which is the specific wave length of this drug. Then the ionization constant is obtained according to the change of absorbance. This way is proved to be simple, applicable and easily operated.
作者 彭惠琦 施国跃 刘敏 徐继明
机构地区 华东师范大学化学系
出处 《华东师范大学学报（自然科学版）》 CAS CSCD 北大核心 2002年第4期54-57,共4页 Journal of East China Normal University(Natural Science)
关键词 去甲柔红霉素 紫外-可见分光光度法 电离常数 抗癌药物 吸光度 蒽环类抗生素 Idabicin UV-Vis ionization constant
分类号 R979.14 [医药卫生—药品] R927 [医药卫生—药学]
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参考文献6

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同被引文献23

  • 1陈晓峰,翟红林,李存红,陈兴国,胡之德.毛细管电泳同时测定酚类系列化合物的表观离解常数[J].兰州大学学报（自然科学版）,2005,41(1):52-56. 被引量：8
  • 2魏永巨,修乃华,李克安,童沈阳.光度法测定有机试剂逐级电离常数的数学理论与计算方法[J].计算机与应用化学,1994,11(3):206-210. 被引量：2
  • 3齐美玲,鲁顺蓉,王鹏.线性滴定法测定盐酸氯丙嗪的含量[J].沈阳药学院学报,1994,11(4):254-256. 被引量：4
  • 4朱志良,梁晓明,张荣华.聚天冬氨酸酸解离常数的测定[J].分析化学,2005,33(12):1722-1724. 被引量：7
  • 5魏锐,王磊,刘强,范林,宋万琚,刘秀丰,赵玉伟.含铁物质中铁元素含量的测定——基于传感技术的实验设计[J].化学教育,2006,27(7):50-51. 被引量：22
  • 6Erdemgil F Z, Sanli S, Sanli N, et al. De'termination of pKa values of some hydroxylated benzoic acids in methanol-water binary mixtures by LC methodology and potentiometry [J]. Talanta, 2007, 72: 489-496.
  • 7Blasko A, Bunton C A, Bunel S, et al. Determination of acid dissociation constants of anomers of amino sugars by ^1H-NMR spectroscopy [J]. Carbohydrate Research, 1997, 298:163-172.
  • 8Perez-Urquiza M, Beltran J L. Determination of the dissociation constants of sulfonated azo dyes by capillary zone electrophoresis and spectrophotometry methods [J]. Journal of Chromatography A, 2001, 917:331-336.
  • 9Liu Huitao, Wang Ketai, Chen Xingguo, et al. Determination of rhein, balcalin and berberine in traditional Chinese medical preparations by capillary electrophoresis with two-marker technique [J]. Biomedical Chromatography, 2004, 18: 288- 292.
  • 10Panigrahi L, Pattnaik S, Ghosal S K. The effect of pH and organic ester penetration enhancers on skin permeation kinetics of terbutaline sulfate from pseudolatex-type transdermal delivery systems through mouse and human cadaver skins [J]. AAPS Pharm Sci Tech, 2005, 6(2) : 167-173.

引证文献5

二级引证文献16

华东师范大学学报（自然科学版）
2002年 第4期

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