骨湿宁治疗风湿性关节炎的实验研究

Experimental studies on Gushining for rheumatic arthritis

目的 :观察骨湿宁的主要药理作用。方法 :采用佐剂、角叉菜胶、尿酸钠等引发大鼠关节炎症或疼痛模型、小鼠热板、醋酸扭体法以及腹腔毛细血管通透性来评价骨湿宁的抗炎、镇痛作用。结果 :骨湿宁能抑制大鼠佐剂性关节炎的原发性和继发性病变 ;抑制角叉菜胶所致的大鼠炎症肿胀 ;对由大鼠尿酸钠关节炎致痛、小鼠热板、醋酸扭体致痛均有明显的镇痛作用 ;并具有降低小鼠腹腔毛细血管通透性、抑制大鼠棉球致组织增生的作用。结论 :骨湿宁具有一定的抗炎。

OBJECTIVE:The antirheumatical effect of Gushining was evaluated in several animal models. METHOD:The antiinflammation and demulcent effect of Gushining was evaluated using the inflammatory rheumatism rat model, hot plate or acetic acid twisted method induced by adjuvant, carrageehan and natrium urate.RESULTS:The results showed that Gushining can alleviate the original and secondary syndromes of adjuvant arthritis in rats,suppress the joint swelling of rats induced by car and joint pain of rats induced by natrium urate,Gushining can also relieve pain in mice induced by hot plate or acetic acid and lower the inflammatory exudation induced by acetic acid.CONCLUSION:Gushining has antiinflammatory and demulcent effect.