脂质体经皮给药研究进展

Advance in studies of liposome transdermal drug delivery system

目的 :分析总结近年来国外脂质体经皮或黏膜给药研究的特点和应用进展。方法 :对近年来脂质体药物特点 ,主要对在皮肤疾病和美容方面 ,对局部伤口的治疗 ,在皮肤损伤和保护中的应用 ,在眼科疾病中的应用进行综述。结果与结论 :脂质体是一种很好的定向药物载体 。

OBJECTIVE:To summarize the advances of liposome transdermal drug delivery studies in recent years.METHOD:This technique provides a simple, clinically relevant approach to deliver therapeutic amounts of biogenic molecules to the skin, with potential application in treating a variety of cutaneous disorders and other diseases. These carriers can transport pharmacological agents, including large polypeptides, through the permeability barriers, such as the intact skin.RESULTS and CONCLUSION:Topically applied liposomes may be capable of targeting the delivery of a wide range of drugs, including macromolecules, into the body. Targeted drug delivery may have profound therapeutic applications for treating several diseases.