尼莫地平固体分散物的制备及其片剂溶出度的研究

The study of Preparation of nimodipine solid dispersion and their dissolution

目的 :提高难溶性药物尼莫地平的溶出速率。方法 :选用 PVP-k3 0 和 PEG60 0 0为载体制备了不同晶型尼莫地平固体分散物和机械混合物 ,比较了它们片剂体外的溶出速率。结果 :尼莫地平固体分散物的片剂溶出度高于机械混合物的 ,低熔点机械混合物片剂溶出度高于高熔点的 ,不同晶型尼莫地平 PEG60 0 0固体分散物片剂体外的溶出速率无显著性差异 ,低熔点尼莫地平 PVP-k3 0 固体分散物的片剂的 90 min累积溶出量比高熔点的高。结论 :不同晶型尼莫地平制备成 PVP-k3 0 和 PEG60 0

OBJECTIVE:To enhanced the dissolution rate of nimodipine, a poorly water soluble substance. METHOD:Different polymorphic forms of nimodipine solid dispersion NMDP PVP k 30 and NMDP PEG6000 and physical mixture were prepared. The dissolution rates of NMDP from solid dispersion NMDP PVP k 30 and NMDP PEG6000 and their physical mixture were also compared.RESULTS:The results showed that the dissolution rate of NMDP from the tablets was obviously greater than that of the physical mixture. The dissolution rate of NMDP(L) of the physical mixture was higher than that of NMDP(H). The dissolution rate of the different polymorphic forms of nimodipine from NMDP PEG6000 solid dispersion has no significant difference. The dissolving percentage(%) of NMDP from NMDP(H) PVP k 30 at tablet 90 minute is lower than that from NMDP(L) PVP k 30 tablet.CONCLUSION:The dissolution rate of NMDP can be improved greatly by coevaporation methods with PVP k 30 and PEG6000 as carriers.