脂肪醇聚氧乙烯醚分子量分布的高效液相色谱法分析

Molecular weight distribution of the polyethenoxy ether of aliphatic alcohol by HPLC

目的 :建立脂肪醇聚氧乙烯醚分子量分布 HPL C的分析方法。方法 :将自制的十二醇聚氧乙烯醚合成 3、5 -二硝基苯甲酸酯 ,用 HPLC法以 (10 % ,9% ,8% ,7% ,6% ,5 % ,4% ,3 % ,2 % ,1% )乙醇的石油醚溶液为流动相 ,在氨基柱上 ,于 2 80 nm波长处作梯度洗脱。结果 :脂肪醇聚氧乙烯醚的分子量 (EO)符合泊松分布。结论 :该方法简单 ,快捷 ,灵敏度高 ,可用于该品的质量控制。

OBJECTIVE:To establish the HPLC analysis methocl for the molecular weight distribution of the polyethenoxy ether of aliphatic alcohol. METHOD:The 3,5 dinitric benzoate derivatives are synthesized using polyethenoxy ether of lauryl alcohol, and stepwise ethanol petroleum solvent(10%～1%) was used on an amino column with the wavelength detected at 280nm by HPLC analysis.RESULTS:The molecular weight distribution of the polyethenoxy ether of aliphatic alcohol followed from Boson distribution.CONCLUSION:The method is simple, rapid, sensitive and could be used as the quality control of these products.