104例脂肪肝患者胰岛素敏感性测定及临床意义

Detection of Insulin Sensitivety in 104 Cases of Fatty Liver Diseases and Its Clinical Significance

目的 :探讨胰岛素抵抗在脂肪性肝炎发病中的作用。方法 :对脂肪肝患者(包括酒精性脂肪肝、非酒精性脂肪肝和肝炎相关性脂肪肝) ,分别测定其空腹血糖(FBG)、空腹胰岛素(FINS)水平 ,比较健康对照组与不同类型的脂肪肝之间的胰岛素敏感性。结果 :酒精性脂肪肝、非酒精性脂肪肝患者与健康对照组比较均存在明显的胰岛素抵抗 ,而肝炎相关性脂肪肝与健康对照比较则不明显。结论 :胰岛素抵抗在酒精性脂肪肝、非酒精性脂肪肝患者发生、发展有相关性。

Objective:To detecte the roles of Insulin Resistance(IR) in the pathogenesis of fatty liver diseases(FLD).Methods:The cases with the fatty liver were selected and classified into 3 types,their FBG and FINS were examined and compared with that of normal subjects.Results:Compared with nomal subjects,all patients with alcoholic fatty liver and no-alcoholic fatty liver had apparent insulin resistance;however,others that induced by hepatitis virus hadn't IR.Conclusions:It was suggested that IR is related to the occurrence and development of alcoholic and no-alcholic fatty liver diseases.