血管紧张素转换酶基因多态性与脑梗死危险因素的关系

Relationship Between Angiotensin Converting Enzyme Gene Polymorphism and Risk Factors in Cerebral Infarction

目的 :探讨ACE基因多态性与脑梗死危险因素的关系。方法 :应用聚合酶链反应技术 (PCR)检测 312例上海地区正常人和32 5例脑梗死患者的ACE基因 ,并调查脑梗死患者危险因素。结果 :①ACEDD基因型在脑梗死患者中年龄≥ 5 0岁组频率为 0 2 46,高于对照组 0 15 1。DD :DⅠ +Ⅱ ,χ2 =5 84(P <0 0 5 ) ,差别有显著意义。②脑梗死患者中有高血压病史 73 8%、高血压病家族史48 6%、脑卒中家族史 32 3% ,明显高于其他危险因素。③ACE基因型与脑梗死患者的体重指数 (BMI)、血压、血糖等危险因素值差异无显著性 (P >0 0 5 )。结论 :ACEDD基因型可能是脑梗死的一个独立危险因素。高血压病、高血压病家族史、脑卒中家族史是脑梗死主要危险因素。

Aim:To explore the relationship between angiotensin converting enzyme (ACE) gene polymorphism and the risk factors in cerebral infarction.Methods:325 patients with cerebral infarction and 312 healthy individuals in Shanghai were studied by using polymorase chain reaction (PCR), and the risk factors of cerebral infaction were assessed by questionnaire, physical examination, and blood tests.Results:(1) ACE DD genotype frequency (0.246) in cerebral infarction group aged more than 50 was higher than that in the healthy control group (0.151). As for DD:DⅠ+Ⅱ, χ 2=5.84, ( P <0.05), there was a significant difference. (2) 73.8% subjects had a history of hypertension, 48.6% subjects had a family history of hypertension, and 32.3% subjects had a family history of stroke. For these patients, the above-mentioned three risk factors were much higher than other risk factors. (3) There was no significant difference among genotypes in terms of body weight index, blood pressure, blood glucose ( P >0 05). Conclusion: ACE DD genotype seemed to be an independent risk factor in cerebral infarction. Hypertension, a family history of hypertension and a family history of stroke were the main risk factors in cerebral infarction. The relationship between ACE gene polymorphism and the risk factors in cerebral infarction should be further studied.