脑梗死患者脑脊液中白细胞介素-6检测的临床价值

Measurement of interleukin-6 in cerebrospinal fluid in patients with cerebral infarction and its clinical value

目的 探讨脑梗死患者脑脊液 (CSF)中白细胞介素 6 (IL 6 )的水平及临床价值。方法 采用酶联免疫吸附双抗体夹心 (ELISA)法 ,检测 2 0例脑梗死患者及 10例对照组CSF中IL 6的水平 ,并进行动态观察。结果 脑梗死患者各时间点的CSF中IL 6的水平 ,显著高于正常对照组 ,3天内达高峰 ,发病初CSF中IL 6的水平与 3个月后的脑损伤容积明显相关 (r =0 .6 3,P <0 .0 5 )。结论 脑梗死患者CSF中IL 6的水平的测定 ,可作为判断脑损伤程度的一项早期指标。

Objective To explore the level of interleukin 6(IL 6) in cerebrospinal fluid(CSF) in patients with cerebral infarction and its clinical implication.Methods The levels of IL 6 in CSF were measured in 20 patients with cerebral infarction and 10 normal controls by using ELISA. Serial observations were performed.Results The CSF level of IL 6 in patients with cerebral infarction significantly increased compared with that of controls during the whole observation penriod, with a peak level within 3 days. The initial level of IL 6 in CSF was significantly correlated with the volume of infarct measured by MRI 2 to 3 months later( r = 0.63 , P < 0.05 ).Conclusion The level of IL 6 in CSF in patients with cerebral infarction may be used to assess the extent of brain damage soon after stroke onset.