摘要
目的 :探讨粘蛋白 MUC5 AC在常年性变应性鼻炎发病中的意义。方法 :采用 PAS染色和免疫组化 SABC法检测了 2 3例常年性变应性鼻炎患者鼻粘膜中粘蛋白 MUC5 AC的表达。结果 :2 3例变应性鼻炎鼻粘膜组织中 PAS染色均为阳性 ,粘蛋白 MU C5 AC染色阳性率为 85 .2 % ,主要表达在粘膜下腺体上皮的杯状细胞中。结论 :粘蛋白 MUC5
Objective: To evaluate the role of mucin MUC5AC in perennial allergic rhinitis.Methods:The expressions of MUC5AC were determined by using periodic adid\|Schiff staining (PAS)and immunochemistric staining (SABC method)in nasal mucosa on 23 patients with perennial allergic rhinitis from November 2001 to April 2002.There were 15 males and 8 females,ranging in age from 16 to 45 years old.Result:The positive rate of PAS was 100 0% and SABC was 85 2% respectively.The expressions of MUC2 and MUC5AC were mainly distributed in cytoplasm of epithelial goblet cells and submucosal glands.Conclusion:Our result showed that the MUC5AC should be an important role in the hypersecretion of liquid in perennial allergic rhinitis.
出处
《耳鼻咽喉（头颈外科）》
2002年第6期359-361,共3页
Chinese Arch Otolaryngology-Head Neck Surg
