中西医结合治疗冠心病前后ET-1、CNP和CGRP联检的临床意义

Clinical Significance of Combined ET-1, CNP and CGRP Detection in Patients with Coronary Heart Disease Treated with Traditional and Western Medicine

目的 :探讨中药络泰和黄芪注射液与西药结合治疗冠心病的效果和作用机制。方法 :用RIA法检测冠心病患者治疗前后血浆中ET - 1、CNP和CGRP水平的变化 ,并与只用西药治疗患者进行比较。结果 :各组冠心病患者治疗前血浆中ET - 1和CNP含量均明显高于对照组 (p <0 0 1) ,CGRP含量明显低于对照组 (p <0 0 1) ;络泰组和黄芪组在治疗后ET - 1、CNP和CGRP含量与治疗前相比均有非常明显的改善 (p <0 0 1) ;单用西药组治疗后ET - 1和CNP水平降低的不明显 (p >0 0 5 ) ,只有CGRP得到明显改善 (p <0 0 1)。结论 :在常规治疗冠心病西药的基础上 ,再加以中药络泰和黄芪注射液 ,可以提高对冠心病的治疗效果 ,优于单用西药治疗。

Objective To investigate the treatment effect and mechanism of LuoTai or Astragale injection together with western mediaine in CHD patients. Methods Plasma ET-1, CNP and CGRP levels were were determined with RIA in CHD patients before and after comined treatment. The values were studied against those in patients treated with western medicine only. Results Before treatment, patients riasma ET-1 and CNP levels were significantly higher ( p <0 01), CGRP level significantly lower ( p <0 01) than those in controls. After combined treat ment, the levels were marhedly changed ( p <0 01), approaching hte controls'. In patients treated with western medicine only, the fall of ET-1 and CNP levels was not significant ( p >0 05); only CGRP levels markedly increased ( p <0 01). Conclusion Combined treatment of LuoTai or Astragale injection with western medicine could result in a bether therapeutic affect than that obtained by western medicine only.