高强度聚焦超声结合放疗治疗直肠癌121例疗效观察

Preliminary results of combined high intensity focused ultrasound and radiotherapy on rectal carcinoma in 121 cases

目的 评价高强度聚焦超声结合放疗对直肠癌的近期疗效。方法 自 1 998年 7月至2 0 0 0年 1 2月对 1 2 1例直肠癌应用FEP BY0 1型高强度聚焦超声体外聚焦热疗机进行热疗和小剂量放疗 ,对病程 1年以上的 43例进行随访。结果 1 2 1例直肠癌患者中CR2 7例 (2 2 % ) ,PR 80例 (66 % ) ,NC1 4例 (1 2 % ) ,总缓解率 88% ,无 1例出现皮肤烧伤 ,脏器穿孔及出血等并发症。 1年生存率 81 %(35/ 4 3) ,2年生存率 77% (2 3/ 30 )。结论 HIFU技术是一种适宜直肠癌的新疗法 ,结合放疗 ,具有疗效显著 ,安全可靠 ,无副作用的优点。

Objective To assess therapeutic effects and safety of high intensity focused ultrasound ( HIFU ) and radiotherapy for the treatment of rectal carcinoma. Methods In combination with low dose of radiotherapy, we treated 121 cases of rectal carcinoma with FEP BY01 type HIFU therapy from Jul.1998 to Dec.2000 and 43 cases were followed up for more than one year. ResultsComplete response (CR) was achieved in 27 cases(22%), partial response (PR) in 80 cases (66%),and no change(NC)was found in 14 cases (12%) with a total response rate of 88 4%.There were no complications. One year survival rate was 81%(35/43) and 2 year survival rate was 77%(23/30). ConclusionHIFU in combination with radiotherapy is a new method to treat rectal carcinoma with significant therapeutic effect and high safety.