摘要
An efficient synthesis of 3,4-dihydropyrimidinones from aldehyde, β-ketoester and urea in ethanol using cobalt chloride hexahydrate or lanthanum chloride heptahydrate as acatalyst was described. Compared to the classical Biginelli reaction, this new method consistentlyhas the advantage of good yields (56%―99%) as well as short reaction tune (4―5 h).
An efficient synthesis of 3,4-dihydropyrimidinones from aldehyde, β-ketoester and urea in ethanol using cobalt chloride hexahydrate or lanthanum chloride heptahydrate as acatalyst was described. Compared to the classical Biginelli reaction, this new method consistentlyhas the advantage of good yields (56%―99%) as well as short reaction tune (4―5 h).
基金
ProjectsupportedbytheNaturalScienceFoundationofShaanxiProvince (No .2 0 0 0H0 3)
