Enantioselective Total Synthesis of Four Styrylpyrone Derivatives

Enantioselective Total Synthesis of Four Styrylpyrone Derivatives

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摘要 The first enantioselective total synthesis of 5-acetoxygoniothalamin 1 and 5-acetoxyisogoniothalamin oxide 2 was achieved through the Sharpless kinetic resolution of racemic secondary 2- furylmethanol 5 and the Mitsunobu reaction. At the same time we developed a short synthetic route for 6R-(+)-goniothalamin 3 and (6R, 7R, 8R)-(+)-goniothalamin oxide 4. And according to this route the configuration of 5-acetoxygoniothalamin 1 was confirmed as (5S, 6S). The first enantioselective total synthesis of 5-acetoxygoniothalamin 1 and 5-acetoxyisogoniothalamin oxide 2 was achieved through the Sharpless kinetic resolution of racemic secondary 2- furylmethanol 5 and the Mitsunobu reaction. At the same time we developed a short synthetic route for 6R-(+)-goniothalamin 3 and (6R, 7R, 8R)-(+)-goniothalamin oxide 4. And according to this route the configuration of 5-acetoxygoniothalamin 1 was confirmed as (5S, 6S).

作者 Xiao Shui PENG An Pai LI Tong Xing WU Xin Fu PAN

机构地区 Department of Chemistry&National Laboratory of Applied Organic Chemistry

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2002年第6期519-520,共2页 中国化学快报(英文版)

基金 We are grateful to the National Natural Science Foundation of China(No.2017223)for financial support

关键词 ENANTIOSELECTIVE 5-acetoxygoniothalamin 5-acetoxyisogoniothalamin oxide 6R-(+)- goniothalamin (6R 7R 8R)-(+)-goniothalamin oxide. Enantioselective 5-acetoxygoniothalamin 5-acetoxyisogoniothalamin oxide 6R-(+)- goniothalamin (6R, 7R, 8R)-(+)-goniothalamin oxide.

分类号 O626 [理学—有机化学]

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Chinese Chemical Letters

2002年第6期

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Enantioselective Total Synthesis of Four Styrylpyrone Derivatives

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