配体量对^(153)Sm-HEDTMP生化性能的影响

INFLUENCES OF THE AMOUNT OF LIGAND ON THE BIOCHEMICAL PROPERTIES OF ^(153)Sm-HEDTMP

研究了配体羟乙基乙二胺三甲撑膦酸 (HEDTMP)的量对配合物153Sm HEDTMP的脂水分配系数、配合物与牛血清白蛋白 (BSA)结合性以及配合物在羟基磷灰石 (HA)上吸附性能的影响。结果表明 ,随着配体量的增大 ,配合物在正辛醇 水中的分配系数减小 ;与牛血清白蛋白的结合率下降 ;在HA上的吸附率有降低的趋势 ,但不明显。根据三项生化性能对153Sm HEDTMP在体内代谢的影响 。

The Effect of the amount of ligand HEDTMP on biochemical properties of 153Sm-HEDTMP is studied. The biochemical properties include partition coeffcient of 153Sm-HEDTMP in n-octanol-water which is measured by shake-flask method,combination characteristic with BSA(bovine serum albumin) which is measured through precipitation by TCA(trichloroacetic acid) and adsorption characteristic on HA(hydroxyapatite) which is measured with the same method used in 153Sm-EDTMP .It is found that ,with the increase in the amount of ligand,partition coefficient of 153Sm-HEDTMP in n-octanol-water decreases,so does combination percentage with BSA,but the adsorption percentage on HA shows a little and unremarkable decrease. Considering the relationships between these three biochemical properties and in vivo metabolism of 153Sm-HEDTMP this study supports the view that an appropriate high amount of ligand should be applied in practical use.