(R)-2-羟基-4-苯基丁酸乙酯的合成

The Synthesis of Ethyl (R)-2-hydroxy-4-phenylbutanoate

综述了血管紧张素转化酶抑制剂类治疗高血压和充血性心力衰竭药物的关键中间体 ( R) -2 -羟基 -4 -苯基丁酸乙酯的合成方法。参考文献 2

Ethyl (R)-2-hydroxy-4-phenylbutanoate is a key intermediate for the syntheses of angiotensin converting enzyme inhibitor(ACEI), which are widely used in clinic as the therapy of hypertesion and congestive heart failure. The synthetic methods of ethyl (R)-2-hydroxy-4-phenylbutanoate were reviewed with 25 references.