摘要
以 3-苄基苯乙酮、异丙醇钠和氯乙酸异丙酯为起始原料 ,采用“一锅煮”方法合成了消炎镇痛药酮洛芬的重要中间体 2 -( 3-苄基苯基 )丙醛 ,总收率 82 %。
Methyl-3-(phenylmethyl)-benzeneacetaldehyde was prepared from 3-benzylacetophenone by condensation, hydrolysis and decarboxylation successively in 'one pot'. The synthetic method was succinct and effective with 82% oveall yield. The title compound is a key intermediate of ketoprofen.
出处
《合成化学》
CAS
CSCD
2002年第5期468-470,共3页
Chinese Journal of Synthetic Chemistry