3-苄基-6-(1-氨基烃基)-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑的合成与波谱表征

Synthesis and Spectral Characterization of 3-Benzyl-6-(1-aminoalkyl)- 1,2,4-triazolo-1,3,4-thiadiazoles

3 苄基 4 氨基 5 巯基 1,2 ,4 三唑与氨基酸在三氯氧磷存在下反应 ,合成 3 苄基 6 (1 氨基烃基 ) 1,2 ,4 三唑并 [3,4 b] 1,3,4 噻二唑 ,其结构经元素分析、红外光谱、核磁共振氢谱、碳谱、质谱等确证 .这是稠杂环接氨基酸残基的首次报道 .

Reaction of 3-benzyl-4-amino-5-mercapto-1, 2, 4-triazole with amino acids in the presence of phosphoryl chloride yielded 3-benzyl-6-(1-aminoalkyl) -1, 2, 4-triazolo [3, 4- b]- 1, 3, 4-thiadiazoles. The structures of these compounds were confirmed by elemental analysis, IR, H-1 NMR, 13 C NMR and MS spectra. This is first report on the synthesis of fused heterocycles to which amino acid residues are attached.