对位取代苯酚氧甙类化合物的相转移催化合成与结构表征

Synthesis and Structural Characterization of p-Substituted Phenyl-β- D-glucoside Compounds by Phase-Transfer Method

为了获得新的活性化合物 ,以溴代四乙酰葡萄糖和对位取代苯酚为原料 ,溴化四丁基铵为相转移催化剂 ,合成了 18个对位取代苯酚氧甙类化合物 ,其产率为 2 0 0 %～ 99 5 %.化合物结构经元素分析 ,IR ,1HNMR表征 ,化合物的生物活性经初步测定 ,其中四种有抑制端粒酶活性 .

p-Substituted phenyl-β-D-glucosides were synthesized in 20.0%～99.5% yields by using tetrabutylammonium bromide as a phase-transfer catalysis. Preliminary tolemerase inhibitive activity of the compounds was determined.