混合稀土对大鼠肝脏中7种酶的小剂量刺激作用

The Hormesis Effect of Rare Earth Elements on Several Enzymes in Rats Liver

研究了常乐 (用于肥料添加剂的一种混合稀土硝酸盐 )对Wistar大鼠肝脏中 7种常见酶 (ALT ,ICD ,AST ,LAP ,ALP ,γ GT ,CHE)活性的变化 ,并用电感耦合等离子体质谱 (ICP MS)测定了稀土在肝脏中的累积情况。结果表明 ,稀土对多种酶表现出低剂量激活、高剂量抑制的小剂量刺激作用 (Hormesis) ,但产生刺激作用的剂量随酶的种类不同而不同 。

The effects of rare earth elements(RE) on the activities of seven enzyme (ALT, ICD, AST, LAP, ALP, γ-GT, CHE) in rat liver have been investigated by analysing the accumulated amount of RE in the rat liver by ICP-MS. The results indicate the occurrence of Hormesis effect on most enzymes studied and the dependence of Hormesis dose-response range on the type and character of the enzymes. No significant relationship was observed between dosage and the accumulation of RE in the rat liver.