C-反应蛋白与冠状动脉病变的相关性及其临床意义

The correlation of C-reactive protein with the coronary angiographic findings

目的 :探讨血浆 C-反应蛋白 (CRP)与冠脉病变的稳定性、程度及范围的关系。方法 :根据冠状动脉造影结果和临床表现 ,将 135例冠心病患者分组比较他们的血浆 CRP水平。结果 :1不稳定型心绞痛患者血浆 CRP水平高于稳定型心绞痛患者 (15 .0± 3.4 vs5 .8± 0 .8m g/ L,P<0 .0 1) ;2冠脉堵塞组患者的血浆 CRP较狭窄组患者高 (18.2± 3.1vs9.3± 1.9mg/ L,P<0 .0 1) ;3多支病变组患者的血浆 CRP明显高于单支病变组患者 (15 .0± 2 .7vs6 .8± 0 .8mg/ L,P<0 .0 1)。结论 :血浆 CRP水平与冠状动脉病变相关 ,对判断冠脉病变稳定性。

AIM:This study examined the correlation of C Reactive Protein(CRP) to the stability,aera and extent of coronary artery culprit lesion.METHODS: 135 patients undergoing coronary angiography were included in the study. Samples for CRP were obtained at admission and measured with enzyme immunoassay.RESULTS:①The concentrations of CRP in the patients with unstable angina were higher than those in the patients with stable angina (15.0±3.4 vs 5.8±0.8 mg/L, P <0 01);②A clear relationship between CRP and the aera and extent of culprit lesion in coronary artery was found(18.2±3.1 vs 9.3±1.9 mg/L & 15.0±2.7 vs 6.8±0.8 mg/L, P <0.01). CONCLUSION:Elevated CRP may predisposes to the destabilization,area and extent of culprit lesion in coronary artery.