微囊型脑膜瘤临床病理、超微结构和免疫组化研究

On the clinicopathology, ultrastructure and immunohistochemistry study of intracranial microcystic meningioma

目的:提高对颅内微囊型脑膜瘤的认识,提高诊断本领。方法:对15例颅内微囊型脑膜瘤进行光镜、超微结构和免疫组化三个方面进行了研究。结果:光镜下肿瘤细胞质淡染有长的突起,间质丰富有许多空泡状微囊。小血管多,肿瘤内无砂粒体或坏死。电镜下,肿瘤细胞胞质伸出指状突起相互围成囊腔,囊内可见束状胶原纤维丝。免疫组化,Vimetin和EMA染色阳性。结论:光镜下该型脑膜瘤具有一定特征,免疫组化有助于该瘤的诊断,电镜可以正确诊断微囊型脑膜瘤。

Purpose: To enhance one's ability to diagnose intracranial microcystic meningioma. Methods: Fifteen cases of intracranial microcystic meningioma have been studied either clinicopathologically, or ultrastructurally or immunohistochemically. Results: The results indicate that electron microscopy and immunohistochemically are very helpful for the diagnosis of the tumor. There was no predilection as to location, however the tumor was more common on the base of skull. Vacuole-like structure and/or vesicular dilatation could be seen in the cytoplasm and capillaries could be observed in between the spindle cells by light microscopy. Under electron microscopy, the processes separated from each other and formed into a cystic structure, and bundles of collagenous fiber could be found in it. In immunohistochemistry, the stains with vimentin and epithelium membrane antigen (EMA) were positive. Conclusions: Intracranial microcystic meningioma has some characteristics under the microscope, immunohistochemistry is helpful in its diagnosis, and election microscopy can confirm this diagnosis.