P27^(Kipl)与食管癌研究的进展

Advances in research on esophagus carcinoma and P27^(Kipl)

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摘要 P27Kipl是近年发现的一个多功能细胞周期蛋白依赖激酶抑制剂(CKI),作为CDK的抑制因子对细胞周期实行负调控。研究表明P27蛋白表达水平及活性的改变与食管癌的发生、发展及预后有关。而其具体的作用机制有待进一步阐明。 P27Kipl is a multifunctional cyclin depedent kinase inhibitor (CKI) that was found recently, and to be regarded as a negative regulative restraining gene of cyclin depedent kinase( CDK) for cell cycle. Investigations suggested that the variations of expres'sion level and activation for p27 protein has relation to occurrence, progress and prognosis of esophagus carcinoma. But its idiographic action mechanism is to be addressed.

作者熊毅敏

机构地区广州军区武汉总医院消化内科

出处《中国癌症杂志》 CAS CSCD 2002年第6期559-562,共4页 China Oncology

关键词食管肿瘤 P27^KIPL 治疗 esophagus neoplasms P27^(Kipl)

分类号 R735.1 [医药卫生—肿瘤]

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1Polyak K, kato JY, Solomon MJ, etal. p27kip1, a cyclin-cdk inhibitor, links transforming growth factor-beta and contactinhibition to cell cycle arrest [ J ]. Genes Dev, 1994, 8 (1) :9 ～22.
2Bullrich F, Maclachlan TK, Sang NL, et al. Chromosomal mapping of members of thecdc2 family of protein kinase, cdk3,cdk6,PISSLRE, and PITALRE, and a cdk inhibitor,p27kipl, to regions involved in human cancer[J]. Cancer Res, 1995,55(6) :1199-1204.
3Sherr CJ. Cancer cell cycles [ J ]. Scirnce, 1996,274 ( 5293 ):1672-1677.
4Rivard N,L'Allemain G,Bartek J,et al. Abrogation of P27kipl by cDNA antisensesuppresses quiescence (GO state ) in fibroblasts[ J]. J Biol Chem, 1996,271 (31):18337-18341.
5Katayose Y,Kim M, Rakkar ANS, et al. Promoting apoptosis: A novel activityassociated with the cyclin-dependent kinase inhibitor p27 [ J ]. Cancer Res, 1997,57 ( 24) :5441-5445.
6Durand B, Gao FB, Raff M. Accumulation of the cyclindependent kinase inhibitorp27/Kip1 and the timing of oligodendrocyte differentiation [ J ]. EMBO J, 1997,16 ( 2 ):306-317.
7Opbascharoensuk V, Fero ML, Hughes J, et al. The cyclindependent kinase inhibitorp27Kip1 safeguards against inflammatory injury [ J ]. Nature Med, 1998,4 ( 5 ): 575-580.
8St Croix B,Florenes VA,Rak JW, et al. Impact of the cyclindependent kinaseinhibitor p27Kip1 on resistance of tumor cells to anticancer agents [ J ]. Nature Med,1996,2 ( 11 ): 1204-1207.
9Tan P, Cady B, Wanner M, et al. The cell cycle inhibitor p27 is an independentprognostic marker in small (T1 a, b) invasive breast carcinomas[ J]. Cancer Res, 1997,57(7): 1259-1263.
10Catzavelos C,Bhattacharya N, Ung YC,et al. Decreased levels of the cell-cycleinhibitor p27Kip1 protein: prognostic implications in primary breast cancer [ J ]. NatureMedicine,1997,3(2) :227-230.

1周慧梅,郭晓青.p27kip1与子宫内膜癌相关性的研究进展[J].农垦医学,2004,26(2):117-119.
2尿道肿瘤[J].国外科技资料目录（医药卫生）,1998(11):101-102.
3刘燕.肠癌患者血清细胞因子表达水平变化的临床研究[J].实用临床医药杂志（护理版）,2007,3(6):90-91.
4生秀杰,王太一.细胞周期蛋白依赖激酶抑制剂——p27kip1研究进展[J].国外医学（遗传学分册）,2000,23(4):173-176. 被引量：1
5邓超,邵增务.p19^(ARF)和p16^(INK4a)在人骨肉瘤中表达的比较研究[J].肿瘤防治研究,2006,33(12):887-889.
6陈雨强,林谋彬,蔡端,马保金.p19^(ARF)和p16^(INK4a)在人胰腺癌、结直肠癌中表达的比较研究[J].中国临床医学,2004,11(3):378-382.
7何杨,吉兆宁,王潞,张帆.乳腺癌中IGF-Ⅰ表达及其与细胞增殖和凋亡相关基因关系[J].临床与实验病理学杂志,2007,23(3):363-365. 被引量：6
8姜剑婷,侯建青,周艳玲,白丽.Skp2和p27^(kip1)在浆液性卵巢肿瘤组织中的表达与临床意义[J].中华临床医师杂志（电子版）,2008,2(1):47-50.
9郑波.p16抑癌基因敲除小鼠髓系细胞增殖特性的研究[J].中华血液学杂志,2002,23(4):211-212.
10钱敏飞,王家东.p63蛋白在甲状腺肿瘤中表达的意义[J].临床耳鼻咽喉头颈外科杂志,2008,22(19):888-890. 被引量：3

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P27^(Kipl)与食管癌研究的进展

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