摘要
P27Kipl是近年发现的一个多功能细胞周期蛋白依赖激酶抑制剂(CKI),作为CDK的抑制因子对细胞周期实行负调控。研究表明P27蛋白表达水平及活性的改变与食管癌的发生、发展及预后有关。而其具体的作用机制有待进一步阐明。
P27Kipl is a multifunctional cyclin depedent kinase inhibitor (CKI) that was found recently, and to be regarded as a negative regulative restraining gene of cyclin depedent kinase( CDK) for cell cycle. Investigations suggested that the variations of expres'sion level and activation for p27 protein has relation to occurrence, progress and prognosis of esophagus carcinoma. But its idiographic action mechanism is to be addressed.
出处
《中国癌症杂志》
CAS
CSCD
2002年第6期559-562,共4页
China Oncology