509例药源性肝损害文献分析

A review of drag-induced liver damage in 509 cases

目的:分析总结近年来药源性肝损害的情况。方法:应用《中国生物医学文献数据库》从1990～2001年进行逐年检索,将符合药源性肝损害诊断标准的文献进行收集分析。结果:抗结核病药、中药制剂和免疫抑制剂是引起肝损害最常见的药物,联合应用具有肝毒性的药物可使药源性肝损害的发生率增高,肾移植者联合应用免疫抑制剂可引起急性肝衰竭,已成为药源性肝损害死亡的主要原因。结论:应重视抗结核病药、免疫抑制剂和某些中药制剂引起的肝损害,肾移植者在应用免疫抑制剂治疗时应特别注意监测肝功能。

Objective: To investigate the drug-induced liver damage in recent years. Method: Literature was retrieved from CBMdisc 1990-2001. Results: Antituberculous agents, traditional Chinese medicines and immunosuppressants were the most common drugs responsible for liver damage(LD). The risk of LD might be increased in patients by concomitant administration of potentially hepatotox-ic drugs. In the cases of renal transplantation, immunosuppressants would result in acute liver failure, the major death cause of LD. Conclusion: Care should be taken for LD caused by the above drugs, with liver function monitoring in renal recipients in particular.