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多发性创伤后血浆血栓调节蛋白的动态变化与意义 被引量：2

Significance of dynamic changes of plasma thrombomodulin after multiple trauma
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摘要 目的　观察多发性创伤患者血浆中血栓调节蛋白 (TM )的变化及其临床意义。方法　 3 5例多发性创伤患者按入院时创伤严重程度的评分值 (ISS)分组 ,A组 14例 ,ISS≥ 16分 ;B组 2 1例 ,ISS <16分。所有患者均于入院当时及第 2、3、5、7天 ,用ELISA法测定血浆TM水平。结果　A组患者血浆中TM水平为 ( 5 5 .45± 13 .14)ng/ml,明显高于B组的 ( 41.81± 16.3 1)ng/ml(P <0 .0 5 )。 17例预后不良者与 18例预后良好者相比 ,血浆TM水平显著升高 (P <0 .0 1)。 Objective To investigate the changes of thrombomodulin(TM) in the plasma of patients after multiple trauma and to explore its clinical significance. Methods ELISA was used to measure the TM levels in group A (ISS≥16, 14 cases) and group B(ISS<16, 21 cases)at day 1, 2, 3, 5, 7 after injury.Results The TM levels in group A were higher than that in group B (P< 0.05), the TM levels of 17 patients with poor outcome were higher than that of 18 cases with good outcome(P< 0.01). Conclusion The dynamic measurement of TM change in patients with multiple trauma may attribute important clinical significance in evaluating the degree of severity of the injury and the prognosis.
作者 黄豪 孙志扬 沈中华
机构地区 同济大学附属东方医院急救创伤中心 南京军区总医院急诊科
出处 《上海医学》 CAS CSCD 北大核心 2002年第12期767-769,共3页 Shanghai Medical Journal
关键词 多发性创伤 血浆血栓调节蛋白 动态变化 Multiple trauma Thrombomodulin
分类号 R641 [医药卫生—外科学]
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参考文献9

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同被引文献15

  • 1Esmon CT, Owen WG. Identification of an endothelial cell cofactor for thrombincatalyzed activation of protein C [J]. Proc Natl Acad Sci USA, 1981,78(4) :2249-2252.
  • 2Remkova A, Kovacova E, Prikazska M, et al.Thrombomodulin as a marker of endothelium damage in some clinical conditions [J ]. Eur J Intern Med, 2000,11(2) :79-84.
  • 3Fujimi S, Ogura h, Tanaka H, et al. Increased production of leukocyte microparticles with enhanced expression of adhesion molecules from activated polymorphonuclear leukocyte in severely injuried patients [J]. J Trauma,2003,54( 1 ): 114-119.
  • 4Ogura H, Kawasaki T, Tanaka H, et al. Activated platelets enhance microparticle formation and platelet-leukocyte interaction in severe trauma and sepsis [J]. J Trauma,2001,50(5): 801-809.
  • 5Yokota H, NaoeY, Nakabayashi M, et al. Cerebral endothelial injury in severe head injury:the significance of measurement of serum thrombomodulin and the von Willebrand factor[J]. J Neurotrauma,2002,19(9) :1007-1015.
  • 6Mori Y, Woda H, Okugawa y, et al. Increased plasma thrombomodulin as a vascular endothelial cell marker in patients with thrombotic thrombocytopenic purpura and hemolytic uremic syndrome [J]. Clin Appl Thromb Hemost, 2002,8 ( 1 ): 87-89.
  • 7Esmon CT, Owen WG. Identification of an endothelial cell cofactor for thrombincatalyzed activation of protein C [ J]. ProcNatl AcadSci USA,1981,78(4) :2249 -52.
  • 8Remkova A, Kovacova E, Prikazska M, etal. Thrombomodulin as a marker of endothelium damage in someclinical conditions [ J ]. EurJ InternMed. 2000,11 (2) :79 - 84.
  • 9Yokota H,NaoeY,Nakabayashi M,et al. Cerebral endothelial injury in severe head injury: the significance of measurement of serum thrombomodulin and the yon Willebrand factor [ J ]. J Neurotrauma,2002,19(9) :1007 - 15.
  • 10HausmannR, Betz P. The time course of the vascular response to human brain injury - an immunohistochemical study [ J ]. Int J Legal Med,2000,113(5) :288 -92.

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上海医学
2002年 第12期

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