中南邵阳、华东南京、西南成都组织胞浆菌感染流行病学调查

INVESTIGATION ON THE EPIDEMIOLOGY OF HISTOPLASM CAPSULATUM INFECTION IN CENTRAL SOUTH (SHAO YANG),EAST OF CHINA(NAN JING) AND WESTERN SOUTH (CHENG DO)

目的 :组织胞浆菌是一种真菌 ,由家禽及鸟类传播 ,可引起人的深部真菌病。我们进行的流调工作 ,对掌握疾病流行情况、制定防治措施及对结核病的防治工作具有重要意义。方法 :调查对象是健康人、住院的肺结核病人、住院的非结核性肺疾患病人。使用的方法是在前臂内侧皮内注射酵母相组织胞浆菌素 (Histolyn -CYL)。同时在另一前臂做PPD皮试 (1∶1万 )。结果 :中南邵阳地区健康人组织胞浆菌素皮试阳性率2 2 .4 0 %。肺结核病人阳性率 31.6 0 %。非结核病肺部疾病阳性率 15 .85 %。华东南京地区健康人阳性率15 .10 %。肺结核病等阳性率 17.74 %。西南成都地区健康人阳性率 2 1.77%。肺结核病人阳性率 5 4 .4 4 %。结论 :组织胞浆菌感染率很高 ,与人文地理条件密切相关 ,差异很大。因此制订防治措施也应有所不同 ,应结合当地具体情况。

Objective:To survey the prevalance of Histoplasma capsulatum infection,to know the different results from the different districts,which were helpful to make the prevalance methods.Methods:Investigation on normal persons,pulmonary tuberculosis (TB) patients and non-tuberculosis (nTB) patients with pulmonary diseases were tested with histoplasmin.Intradermal skin test with 0.1ml of standard antigens was performed on the volar surface of the forearm.Any reaction to the antigen of 5.0 mm in diameter of induration in 48 hours was considered positive.Results:In central south (Shao Yang),the positive skin reaction rate of normal persons was 22.40%,in TB patients was 31.60%,n-TB patients was 15.85%.In the east of China (Nanjing),the positive skin reaction rate of normal persons was 17.74%,in TB patients was 17.74% .In western south (Chengdo),the positive skin reation rate of normal persons was 21.77%,in TB patients was 54.44%.Conclusions:The rate of Histoplasma capsulatum infection is very high.Significant differences of positive skin reaction rate were found between the western part of China and the eastern part of China.The rate in the western part of China is higher than in the Eastern part of China.