摘要
目的 :研究特发性中枢性性早熟女孩 (ICCP)青春各期血清胰岛素样生长因子 -Ⅰ (IGF -Ⅰ )和胰岛素生长因子结合蛋白3 (IGFBP3 )的变化规律。方法 :测定 2 2例处于青春各期的ICCP女孩的血IGF -Ⅰ和IGFBP3水平及接受治疗后IGF -Ⅰ水平 ,同时以 12例正常青春前期女孩作为对照组。结果 :ICCP女孩青春早、中、晚期IGF -Ⅰ和IGFBP3 均高于对照组 ,IGF -Ⅰ和IGFBP3 与青春分期正相关。促性腺激素释放激素类似物(GnRH -a)治疗 6个后IGF -Ⅰ无显著改变。结论 :ICCP女孩血IGF -Ⅰ和IGFBP3 水平在青春早期显著增加 ,与青春发育进程平行。IGF -Ⅰ可以是青春发动的信号因子。
Objective:To investigate the pattern IGF-Ⅰ and IGFBP-3 concentrations in girl with ICCP at different pubertal.Methods:Serum IGF-Ⅰ and IGFBP-3 concentrations were detected in 22 girls with ICCP at different pubertal stages and the level of IGF-Ⅰ after treated. 12 age-matched prepubertal girls were served as controls.Results:Serum IGF-Ⅰ and IGFBP-3 concentrations in early, middle and late pubertal stages in ICCP girls were significantly higher than that of the control group.Serum IGF-Ⅰ and IGFBP-3 concentrations correlated with Tanner stages, Serum IGF-Ⅰ concentrations remained unchangeable after treatment. Conclusion:Both Serum IGF-Ⅰ and IGFBP-3 concentrations increased significantly in early stage of girls with ICCP,paralleling with the pubertal development. IGF-Ⅰ may be the signal of the youth start.
出处
《中国现代医学杂志》
CAS
CSCD
2002年第24期55-56,共2页
China Journal of Modern Medicine
