慢性肾炎常见证型的血清卵磷脂胆固醇酰基转移酶及高密度脂蛋白含量分析

Study on the Relationship Between Common Patterns and Serum Levels of LCAT、HDL_2 and HDL_3lp in Chronic Glomerulonephritis

目的探讨慢性肾小球肾炎 (CGN)患者常见中医证型的血清卵磷脂胆固醇酰基转移酶 (LCAT)活性水平与高密度脂蛋白亚组分 (HDL亚组分 )含量及意义。方法选择CGN患者 95例 ,中医证型分为肺肾气虚 1 6例 ,脾肾阳虚 2 7例 ,肝肾阴虚 3 2例 ,气阴两虚 2 0例。正常对照组 3 0例 ,采用改良Sperry自身底物法检测LCAT活性。结果CGN 4个不同中医证型中LCAT活性及HDL亚组分含量与正常对照组比较有非常显著性意义 (P <0 .0 5 ) ,且各证型之间LCAT活性水平均有显著性差异 (P <0 .0 5 )。结论LCAT活性水平可作为CGN肺肾气虚、气阴两虚、肝肾阴虚、脾肾阳虚型辨证诊断的参考指标。

?Objective To explore the relationship between common patterns of chronic glomerulonephritis(CGN) and the serum levels of LCAT?HDL 2 and HDL 3 in cases with chronic glormerulonephritis. Methods 95 patients with CGN were divided into four groups,i.e. Lung and Kidney Qi Deficiency (LKQD), Spleen and Kidney Yang Deficiency (SKYD), Liver and Kidney Yin Deficiency (LKYD), and both Qi and Yin Deficiency (QYD), and 30 healthy people taken as the normal control group. Then, LCAT and HDL activity were determined by Sperry method. Results The levels of serum LCAT and HDL 2 in CGN patients with LQKQD?SYKYD?LYKYD and SYKYD were markedly lower than those in control group(P< 0.05 ), while the levels of HDL 3 were markedly higher than those in control group(P<0.05). Conclusion The LCAT activity may offer a reference index to the diagnosis of TCM syndromes in CGN. 〔