血清降钙素原测定在感染性疾病中的诊断意义

The clinical significance of serum procalcitonin in the diagnosis of infectious diseases

目的 :探讨血清降钙素原 (PCT)检测在感染性疾病中的诊断意义。方法 :对 342例各种感染性疾病患者采用半定量固相免疫测定法测定患者血清PCT水平 ,PCT水平分为 <0 .5ng /ml,0 .5～ <2 .0ng /ml,2 .0～ <10 .0ng /ml和≥ 10ng /ml4个等级。结果 :若以血清PCT≥ 0 .5ng /ml为阳性阈值 ,则血清PCT检测对细菌感染 (含立克次体病 )诊断的敏感性为75 .0 % ,特异性为 70 .2 % ,阳性预测值为 4 5 .0 % ,阴性预测值为 89.6 % ,阳性似然比为 2 .5 1,阴性似然比为 0 .35。结论 :血清PCT是细菌感染的重要指标 ,其诊断价值明显优于外周血白细胞计数和分类 ;血清PCT水平高低可作为是否使用抗菌药物的参考依据。

Objective: To investigate the clinical significance of serum procalcitonin (PCT) in the diagnosis of infectious diseases. Methods: Serum PCT were measured by semi quantitative solid phase immunoassay, and serum concentration of PCT levels were categorized into four groups:<0.5?ng /ml, 0.5-2?ng /ml, 2.0-<10.0?ng /ml and ≥10?ng /ml. A total of 342 patients with various infectious diseases were enrolled in this study. Results: Take serum PCT ≥0.5ng /ml as a threshold, the sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio of the test in diagnosing bacterial infectious diseases were 75.0%,70.2%,45.0% ,89.6%,2.51 and 0.35, respectively. Conclusions: The results suggest that serum PCT is a marker for the cliagnosis bacterial infections,it is better than white blood cell count ,and serum PCT level may be used as an indicator for antibacterial therapy.