摘要
目的 观察常规剂型与控释剂型硝苯吡啶治疗老年原发性高血压的疗效及心率、血脂、血糖、肾功能的影响。方法 选择本院住院患者 98例 ,均确诊为老年原发性高血压。病程 8个月至 2 0年 ,随机分成两组 :5 1例给予口服硝苯吡啶控释片 ,每日 1次 30mg。 4 7例给予口服硝苯吡啶片 ,每日 3次 ,每次 10mg ,观察疗程 6周。结果 与硝苯吡啶组比较 ,硝苯吡啶控释片降压效果更明显 ,不干扰HRV昼夜变化节律 ,两组患者治疗前后血糖、血脂无明显变化。结论 硝苯吡啶及其控制释片均可有效降低血压 ,对糖脂代谢无影响 ,硝苯吡啶控制片降低血压更平稳和持久。
Objective To observe the effects of nifedipine and its control releasing tablet on blood pressure,blood lipid,blood glucose and renal function aged in patients with hypertension.Methods 98 aged patients with hypertension were divided into nifedipine group(10mg,three times a day) and control releasing nefidipine group(30mg,once a day) for 6 weeks.Results Compared to the nifedipine group,the reduction of blood pressure was more significant in control releasing nifedipine group without interfering the HRV day and night rhythm,bolld lipid,blood glucose and renal function had no obvious changes in both groups.Conclusion Both nifedipine and its control releasing tablet all can reduce blood pressure effectively,have no influence on blood lipid,blood glucose and renal function,but control releasing nifediping can get smoother and more sustainable blood pressure control than nifedipine.
