番鸭肝白点病病理学研究

Pathology of Muscovy duck liver white-spots disease

应用番鸭肝白点病分离毒人工感染1日龄雏番鸭,并对发病鸭的肝、脾、心、肺、肾、胰、法氏囊、胸腺、脑和肠等10种器官组织进行了病理组织学观察。结果表明,试验感染发病鸭特征性病理变化主要为肝脾表面及切面的灰白色坏死点;显微结构变化表现为各器官不同程度变性、细胞溶解坏死及血管扩张充血,病灶区及血管周围淋巴单核细胞明显浸润;免疫器官脾、胸腺和法氏囊淋巴细胞变性坏死,数量明显减少;其特征性显微结构变化主要为肝组织程度不一的脂肪变性和空泡变性,小空泡融合成网眼状大空泡或肝细胞呈现局灶性溶解,并见淋巴单核细胞从病灶的周边逐渐向中心浸润,最后形成细胞性结节;脾脏淋巴细胞坏死,数量减少,网状结缔组织显露。

The pathologic changes of liver, spleen, heart, lung, kidney, pancreas, bursa, thymus, cerebrum and intestines of Muscovy ducks infected experimentally with the isolated strain of Muscovy duck liver white-spots disease were observed. The specific pathological changes of diseased Muscovy ducks appeared mainly gray-white spot on the surface and parenchyma of liver and spleen. The microstructure changes showed various degrees of degeneration and vasodilation and hyperemia, and lympho-monocytes infiltration in the foci and perivascular regions of the most organs inspected i The immune-organs such as spleen, bursa of Fabricius and thymus appeared lymphocytes degeneration and necrosis. The typical changes were that the liver cell appeared various extents of fatty-and vacuole-degeneration and focal cytolysis necrosis, lympho-monocytes infiltration from peripheral to central focus and finally forming cellular-node. Most of lymphocytes vanished and the reticular connective tissues appeared in the spleen.