西安市新生儿促甲状腺激素水平4年调查结果分析

Analysis on neonatal TSH results for four years in Xi`an

目的 通过检测新生儿促甲状腺激素 ( TSH )水平 ,诊断先天性甲状腺功能低下症 ,评价西安市新生儿碘营养状况。方法 采用滤纸片 (全血 ) TSH酶联免疫测定方法。结果 4年共测定新生儿脐带血 45 0 4份 ,TSH>5 m U / L者 ,1997年为 35 .5 % ,1998年为 2 4.6 % ,1999年为 19.6 % ,2 0 0 0年为 19.0 %。>30 m U / L的有 7例 ,经复查确诊 1例为先天性甲状腺功能低下症 ,甲低检出率为 0 .2 2‰。结论 西安市新生儿碘营养状况有明显改善 ,但仍存在碘营养不足 ,建议加强对孕妇及婴幼儿等特需人群的补碘工作。

Objective To determine neonatal TSH level for diagnosing congenital hypothyroidism, and assessing neonatal iodine nutrition condition.Methods ELASA was used for neonatal TSH in dried blood spots.Results 4 504 neonates had been determined during 4 years. Neonates with TSH over 5 mU/L was 35.5 per cent in 1997,24.6 per cent in 1998,19.6 per cent in 1999 and 19.0 per cent in 2000.Among 7 cases with TSH over 30 mU/L,1 was confirmed with congenital hypothyroid by rechecking. That is to say congenital hypothyroidism rate is 0.022 per cent.Conclusions The iodine nutrition of neonates in Xi'an has been improved,but it was still insufficient. We suggested that iodine supply on pregnant women and infants should be strengthened.