雌激素与自身免疫性疾病

Estrogen in autoimmune diseases

自身免疫性疾病的发病存在明显的性别差异 ,女性的发病率常高于男性。文章就雌激素在自身免疫性疾病发生机制中的作用 ,特别是近年来雌激素对免疫细胞信号传导、细胞分化、下丘脑 -垂体 -肾上腺 ( HPA )轴的激活、自身免疫性疾病的发生和缓解等方面的研究作一介绍 ,进一步探讨雌激素调节异常对自身免疫性疾病发生的影响。

Many observations proposed that there is a significant gender difference in autoimmune diseases.The predominance of autoimmune diseases among women suggests that sex hormones,especialy,estrogen may contribute to susceptibility.The aim of the review to summarize recent progress about the effects of estrogen,acting through specific receptors on target cells,on signaling,differentation of target cells,on the activity of the hypothalamic-pituitary-adrenal(HPA) axes and on the decrease in autoimmune diseases severity.These progress,no doubt,are important in understanding the pathogenesis of autoimmune diseases.