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人可溶性4-1BB蛋白分子表达载体的构建 被引量：1

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摘要 4-1BB分子是近年来发现的一种共刺激分子,属肿瘤坏死因子受体/神经生长因子受体(TNFR/NGFR)超家属成员,表达于活化的T淋巴细胞表面,以CD8+T细胞为主.
作者 沈丽琴 徐颖 张学光
机构地区 苏州大学生物技术研究室
出处 《南京医科大学学报（自然科学版）》 CAS CSCD 北大核心 2003年第1期80-81,共2页 Journal of Nanjing Medical University(Natural Sciences)
关键词 可溶性4-1BB 表达载体 逆转录-聚合酶链反应 重组表达质粒
分类号 Q78 [生物学—分子生物学]
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参考文献5

  • 1Bretcher PA. A two-step, two-signal model for the primary activation of precusor helper T cells[J] . Proc Natl Acad Sci USA,1999, 96(1): 185 - 190.
  • 2Cohn MA tCannons JL, Lau P, Ghumman B, et al. 4-1BB ligand induces cell indivision, sustains su rvial, and enhances effector function of cd4 and cd8 t cell with similar efficacy[J] . J Immunity, 2001, 167(3): 1313 - 1324.
  • 3Guinn BA, Bertram EM, Debenedette MA, et al. 4-1BBL enhances antitumor responses in the pesence or absence of CD28 but CD28 is equired for protective immunity against parental tumors [J]. Cell Immunol, 2002, 25(1):56-65.
  • 4Kwon B, Lee HW, Kwon BS. New sights into the rle of 4-1BB in immune responses: beyond CD8+ T cells [J]. Trends Immunol,2002, 23(8): 378 -380.
  • 5Paifer E, Margolles E, Cremata J, et al. Efficient expression and secretion of recombinant alpha amylas in pichia pastoris using two different signal sequences[J]. Yeast, 1994, 10:1405 - 1415.

同被引文献10

  • 1Zhou Z, Kim S, Hurtado J, et al. Characterization of human homologue of 4-1BB and its ligand [J]. Immunol Lett, 1995, 45:67-73
  • 2Cheuk AT, Mufti GJ, Guinn BA. Role of 4-1BB: 4-1BB ligand in cancer immunotherapy [J]. Cancer Gene Ther,2004, 11 : 215-226
  • 3Kirchner S, Boldt S, Kolch W, et al. LPS resistance in monocytic cells caused by reverse signaling through transmenbrance TNF(m TNF) is mediated by the MAPK/ERK pathway[J]. J Leukoc Biol, 2004, 75:324-336
  • 4Wen T, Bukczynski J, Watts TH. 4-1BB Ligand-Mediated Costimulation of Human T Cells Induces CD4 and CD8 T Cell Expansion, Cytokine Production, and the Development of Cytolytic Effector Function [J]. J Immunol, 2002, 168:4897-4906
  • 5Bertram EM, Dawicki W, Sedgmen B, et al. A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo [J]. J Immunol, 2004, 172:981-988
  • 6Ju SW, Ju SG, Wang FM, et al. A functional anti-human 4-1BB ligand monoclonal antibody that enhances proliferation of monocytes by reverse signaling of 4-1BBL [J].Hybrid Hybridomics, 2003,22:333-338
  • 7Arens R, Nohe MA, Tesselaar K, et al. Signaling through CD70 regulates B cell activation and IgG production [J]. J Immunol, 2004, 173:3901-3908
  • 8Langstein J, Schwarz H. Identification of CD137 as a potent monocyte survival factor[J]. J Leukoc Biol, 1999,65:829-833
  • 9Langstein J, Becke FM, Sollner L, et al. Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation [J]. Biochem Biophys Res Commun, 2000,273:117-122
  • 10Salih HR, Kosowski SG, Haluska VF, et al. Constitutive expression of functional 4-1BB (CD137) ligand on carcinoma cells[J]. J Immunol, 2000,165:2903-2910

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南京医科大学学报（自然科学版）
2003年 第1期

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