格拉司琼预防颅脑外科手术后恶心呕吐的临床研究

Clinical observation of granisetron in preventing postoperative nausea and vomiting following supratentorial craniotomy

目的 :观察格拉司琼预防颅脑外科手术后恶心呕吐的效果。方法 :70例ASAI～Ⅱ择期开颅手术病人 ,随机分为格拉司琼组和对照组 ,两组病人在缝合头皮时分别静脉注射格拉司琼 3mg或生理盐水 ,观察术后 2 4h、4 8h和 72h恶心呕吐的次数和程度。结果 :格拉司琼组恶心呕吐发生率及程度低于对照组 (2 5 7%vs5 7.1% ,P <0 .0 1) ,严重恶心伴呕吐发生率亦低于对照组 (17 2 %vs4 8.6 % ,P <0 .0 1) ,且不影响病人神志的恢复。结论

Objective To observe the prophylactic effect of granisetron on postoperative nausea and vomiting (PONV) after supratentorial craniotomy. Methods Seventy ASA I～Ⅱ patients undergoing elective supratentorial craniotomy were randomly and double bindly divided into two groups: control group (Group C, n=35) and granisetron group (Group G, n=35). All the patients received either 0.9% NS (Group C) or granisetron 3 mg (Group G) via intravenous injection. The incidences of postoperative nausea and vomiting were recorded at 24 h, 48 h, 72 h after supratentorial craniotomy. Results The incidence of PONV in Group G was lower than that in Group C (25.7% vs 57.1%, P<0.01). The incidence of server nasea with vomiting or vomiting in Group G was lower than that in Group C (17.2% vs 48.6%, P<0.01). Conclusion Granisetron can be used effectively and safely to prevent PONV in supratentorial craniotomy.