G蛋白β3亚基基因C825T多态性与抑郁症及SSRI和SNRI类抗抑郁药疗效关系的探讨

The Relationship Between the C825T Polymorphism of the G-Protein β 3 Subunit and Depression with SSRI,SNRI Treatment

目的:研究G蛋白β3亚基基因C825T多态性与抑郁症及治疗是否存在相关性。方法:采用聚合酶链式反应-限制性片段长度多态性分析（PCR-RFLP）技术对140例抑郁症患者和100例健康志愿者进行基因型分析;用HAMD评定抑郁症的疗效。结果:抑郁症Gβ3基因基因型频率（CC20.7％,CT31.4％,TT47.9％）、等位基因频率（C3.64％,T63.6％）;与正常对照组基因频率（CC27.0％,CT51.0％,TT22.0％）、等位基因频率（C52.5％,T47.5％）比较具有显著性差异;不同基因型抑郁症患者经4周SSRI、SNRI类抗抑郁药治疗后,HAMD总分均显著下降,减分率有显著差异。结论:本研究提示在中国人群中G蛋白β3亚基基因C825T多态性与抑郁症及抗抑郁药疗效有关。

OBJECTIVE: To investigate the relationship between G-protein β3 subunit gene polymorphism and depressive patients in Chinese population. METHODS: Polymerase chain reaction combined with restriction enzyme digestion was used to detec the polymorphism of G-protein β3 subunit gene in 140 depressive patients and 100 controls. The depressive states were assessed with HAMD. RESULTS:There were significant differences of the G-protein β3 subunitPolymorphism genotypes and alleles between 140 depressive patients (CC20.7%;CT31.4%;TT47.9%;C36.4%;T63.6%) and 100 controls (CC27.0%;CT51.0%;TT22.0%;C52.5%;T47.5%). The reductive ratio of HAMD scores were significant differences in depressive patients with different G-protein β3 subunit genotype. CONCLUSION:The C825T polymorphism of G-protein β3 subunit gene was associated with depression and antidepressant responses in Chinese.