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硫嘌呤甲基转移酶分子机制研究进展 被引量：2

Molecular Mechanisms of Genetic Polymorphism of Thiopurine S-Methyltransferase (TPMT)
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摘要 硫嘌呤甲基转移酶（TPMT）在硫嘌呤类药物的体内代谢中起着关键作用,其活性水平与药物效应及毒副作用密切相关。TPMT活性具有遗传多态性和种族差异。TPMT酶活性降低或缺乏与其基因突变密切相关。对TPMT遗传多态性分子基础的研究具有重要意义。本文综述有关TPMT基因表达调控和TPMT基因突变的分子机制的研究进展。 Thiopurine s-methyltransferase (TPMT) plays an important role in the metabolism of thiopurines. Phenotypic polymorphism of TPMT in different populations have been widely studied. TPMT genotype correlates well with in vivo enzyme activity in erythrocytes and is closely associated with risk of toxicity. Genetic mutations are responsible for TPMT deficiency. It is very important to study the molecular basis for altered TPMT activity. This article reviews the genomic structure and genetic mutation of TPMT.
作者 张建萍 黄民 吴珏珩 关永源
机构地区 中山大学药学院临床药理教研室 中山大学中山医学院药理教研室
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2002年第6期448-451,474,共5页 The Chinese Journal of Clinical Pharmacology
关键词 硫嘌呤甲基转移酶 分子机制 研究进展 基因结构 基因突变 thiopurine S-methyltransferase (TPMT), genomic structure, genetic mutation
分类号 R968 [医药卫生—药理学]
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参考文献20

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二级参考文献3

共引文献5

同被引文献18

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中国临床药理学杂志
2002年 第6期

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