圣愈汤免疫与抗氧化作用研究

Effect of Shengyu Decoction on immunity and antioxidation

目的 :观察圣愈汤 (熟地 ,党参 ,黄芪 ,当归等 )对小鼠免疫调节与抗氧化作用。方法 :圣愈汤 2 .0 ;4 .0 g·kg-1连续灌胃小鼠 7～ 15天测定正常与失血小鼠碳廓清率 ,血清溶血素 ,迟发性过敏性和血清SOD与LPO。此外进行小鼠抗疲劳 ,抗寒冷与抗高温作用观察。结果 :圣愈汤 2 .0 ;4 .0 g·kg-1可使正常与失血小鼠血清SOD活性增强 (P <0 .0 5 ) ,LPO含量降低 (P <0 .0 5 ) ;碳廓清率 ,血清溶血素水平 (P <0 .0 5 ,P <0 .0 1)DTH(P <0 .0 5 )明显的增强。还可明显延长小鼠抗疲劳 ,抗高温与抗寒冷的存活时间 (P <0 .0 5 ,P <0 .0 1)。结论 :圣愈汤有增强免疫的作用和良好的抗氧化能力 。

Objective:To observe the effect of Shengyu Decoction (Rhizoma Rehmannine Praeparatae, Radix Codonopsis Pilosulae, Radix Astragali seu Hedysari, Radix Angchcae sinensis, etc.) on regulation of immunity and antagonization of lipid peroxidation in normal mice and post hemorrhagic mice.Methods: Normal mice and the mice that has lost blood were administered Shengyu Decoction with doses of 2.0 g·kg -1 and 4.0 g·kg -1 , and after 7-15 days, carbon clearance rate, serum hemolysin, serum SOD and LPO were determined. Results: Shengyu Decoction can significantly increase the rate of cabon clearance, hemolysin ( P < 0.05 ; P < 0.01 ) and BDTH ( P < 0.05 ). and to improve longevity of mice under the fatigue, cold and high temperature circumstance ( P < 0.05 ). Conclusions: Shengyu Decoction can increase immunity and antagonize lipid peroxidetion, therefore it has ability to resist harmful stimulus.