系统性红斑狼疮病人终末期肾衰前后狼疮活动性比较

Comparison of Disease Activity in Patients with Systemic Lupus Erythematosus Before and After the Onset of End-stage Renal Failure

目的 :比较系统性红斑狼疮 (SLE)病人在终末期肾衰前后狼疮的活动性。方法 :对 5 5例以透析治疗的SLE病人进行分析 ,确定狼疮的活动性 ,依照SLE疾病的活动性指数 ,即SLEDAI(SLEDiseaseActiv ityIndex)。结果 :大多数病人肾功能的恶化是在 2年多的时间里缓慢进展的。终末期肾衰开始透析后 ,最大的肾脏外疾病活动性和药物使用明显减少。透析的 5年生存率为 89%。结论 :SLE病人终末期肾衰后依靠透析有良好的生存率。他们的狼疮活动性在透析过程中减轻 。

Objective:To compare disease activity in patients with systemic lupus erythematosus (SLE) before and after the onset of end-stage renal failure. Methods:Records of 55 patients with dialysis were reviewed,disease activity was measured according to the SLE Disease Activity Index (SLEDAI).Results:In the majority of patients,deterioration of renal function was slowly progressive over more than 2 years.After the initiation of dialysis for end-stage renal failure,maximal extrarenal disease activity end use of medication decreased markly.Over all survival with dialysis was 89% after 5 years.Conclusion:Patients with SLE have excellent survival rates with dialysis,their disease activity is diminished during dialysis but not abolished.