生长素在少精子症中的应用探讨

Exploratory Study on the Application of rhGH in Patients with Spermacrasia

〖目的〗探讨基因重组人生长素(rhGH)在少弱精子症中的应用价值.〖方法〗66例诊断为特发性少精子症患者,随机分为A、B两组:A组31例,使用rhGH治疗,2次/周肌注,每次4.5 IU,共用16周;B组35例,给予金施尔康(多种维生素制剂)1次/d口服,共16周.治疗前后作精液分析.〖结果〗66例参加有效率统计,A组有效率42.0%,B组25.4%.差异有显著性(χ2=4.686,P＜ 0.05).〖结论〗rhGH能有效地改善睾丸生精内环境,促进精子的生成.

Objectives To explore the applying value of gene recombinant human growth hormone (rhGH) in spermacrasia. Methods Sixty-six patients diagnosed as idiopathie spermacrasia were randomly divided into two groups: Group A and Group B. Thirty-one patients in group A were injected with 4.5 IU rhGH intramuscularly for 16 weeks, twice /wk. while Gold Theragran(Multi-Vitamins with Minerals) was administered orally for the same duration in 35 patients of group B , one pill/d . The sperms of all patients in both groups were examined before and after the therapy. Results The effective rates of treatment in group A and B were calculated to be 42.0% and 25.4% , respectively, showing significant difference between both groups ( x=4.686, P <0.05). Conclusion rhGH may stimulate spermatogenesis by improving effectively the internal environment of sperm production in the testes.