苯磺酸左旋氨氯地平联合贝那普利治疗2型糖尿病肾病合并高血压疗效观察

Combination of plevamlodipine with benazepril in the treatment of type 2 diabetes with hypertension

目的观察苯磺酸左旋氨氯地平与贝那普利联合治疗2型糖尿病肾病合并高血压人群的降压疗效及其对肾的保护作用。方法将80例糖尿病肾病合并高血压患者随机分为两组,均给予糖尿病治疗。对照组给予贝那普利10mg/d,实验组给予贝那普利10mg/d+苯磺酸左旋氨氯地平2.5mg/d。两组均治疗12周,观察降压疗效,治疗前后用双缩脲法测定24h尿蛋白定量。结果两组治疗前后收缩压、舒张压均有显著变化(P<0.01),联合组降压效果优于对照组。两组治疗后24h尿蛋白定量水平均有下降,且联合组较对照组下降明显。结论苯磺酸左旋氨氯地平与贝那普利联合治疗2型糖尿病肾病合并高血压人群,降压疗效确切,不仅明显减少了蛋白尿的生成,而且对肾功能有保护作用。

Objective To observe the anti-hypertensive and renal pretective effect of combination of plevamlodipine with benazepril on patients with type 2 diabetes with hypertension.Methods Eighty patients with type 2 diabetes with hypertension were randomly divded into two groups with 40 cases each.The patients in control group were received benazepril 10mg/d only,plevamlodipine 2.5 mg/d+benazepril 10 mg/d on patients in test group and treatment period of 12 days.The anti-hypertensive clinical effect and biuret method with 24h urinary protein determination were recorded.Results Systolic and diastolic blood pressure in all patients decreased significantly(P<0.01),and decreased significantly in test group than those in the control group.Conclusion Combination of plevamlodipine with benazepril has exact step-down effect and renal protective effect,as well as decreases significantly proteinuria.