持续气道正压通气治疗对阻塞性睡眠呼吸暂停综合征患者体内SOD、GSH-PX和MDA水平的影响

Effect of continuous positive airway pressure on the level of SOD,GSH-PX and MDA in the patients with obstructive sleep apnea syndrome

目的研究持续气道正压通气(CPAP)后阻塞性睡眠呼吸暂停综合征(OSAS)患者体内超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)活力和丙二醛(MDA)含量的变化。方法选择OSAS患者52例行SOD、GSH-PX活性和血清MDA含量检测;对OSAS患者行持续气道正压通气治疗3个月后,重新检测SOD、GSH-PX和血清MDA含量,并选择50例健康人作为正常对照。结果SOD、GSH-PX活性和血清MDA含量,正常对照组分别为(94.15±12.53)U/ml、(148.36±12.24)mIU/ml、(7.87±2.82)nmol/ml;OSAS患者含量分别为(69.48±10.79)U/ml、(110.04±11.89)mIU/ml、(20.17±2.57)nmol/ml;持续正压通气(CPAP)治疗3个月后,OSAS患者的SOD、GSH-PX活性和血清MDA含量分别为(90.36±13.19)U/ml、(146.63±14.54)mIU/ml、(8.21±2.73)nmol/ml,与正常对照组相比,OSAS患者MDA明显升高,SOD、GSH-PX活性显著降低,差异均有统计学意义(P<0.01);CPAP治疗3个月后,OSAS患者的SOD、GSH-PX活性、MDA含量与正常对照组相比差异无统计学意义(P>0.05)。结论OSAS患者体内存在严重的氧自由基代谢失衡,CPAP治疗3个月后,氧自由基代谢可基本恢复正常。

Objective To explore the change of SOD,GSH-PX and MDA in patients with obstructive sleep apnea syndrome(OSAS)after three months treatment with continuous positive airway pressure(CPAP).Methods The contents of SOD,GSH-PX and MDA were detected in 52 patients with OSAS before and three months treatment with CPAP,and then compared the results with 50 healthy controls.Results The contents of SOD,GSH-PX and MDA were 94.15±12.53U/ml,148.36±12.24mIU/ml and 7.87±2.82nmol/ml respectively in the healthy people,69.48±10.79U/ml,110.04±11.89 mIU/ml and 20.17±2.57 nmol/ml respectively in patients with OSAS,and 90.36±13.19U/ml,146.63±14.54 mIU/ml and 8.21±2.73 nmol/ml in patients with OSAS after three-month CPAP treatment.The level of MDA was higher in patients with OSAS than that in the healthy people(P<0.01).The levels of SOD and GSH-PX were lower in patients with OSAS than those in the healthy people(P<0.01),but three months after CPAP treatment,they were not significantly difference with those of the healthy people(P>0.05).Conclusion The levels of the oxygen free radicals are imbalance in the patients with OSAS,which can get well after three-month CPAP treatment.