血浆脂联素水平与男性高血压病患者的冠脉病变相关性研究

Correlation between the level of serum adiponectin and the severity of coronary artery disease in male patients with hypertension

目的探讨男性高血压病(HBP)患者血浆脂联素(APN)水平与冠脉病变程度的相关性,寻找能够早期预测男性高血压病患者并发冠脉病变程度的生化指标。方法入选80例因胸闷胸痛入院行冠脉造影术的男性HBP患者,其中单纯HBP患者20例,HBP合并CHD患者60例,对所有患者进行冠脉Gensini评分并检测其血浆APN水平。结果男性HBP患者的血浆APN水平与冠脉Gensini积分呈负相关(r=-0.639,P<0.05)。结论血浆APN水平与男性HBP患者冠脉病变程度显著相关,有助于临床评价男性HBP患者的冠脉病变程度。

Objective To investigate the correlation between the level of serum adiponectin(APN) and the severity of coronary artery disease(CHD) in male patients with hypertensive disease(HBP),and to find the new plasma markers to evaluate the severity of CHD.Methods 80 male paients with HBP were divided into the simple hypertensive group(20 cases) and the group of the HBP combined with CHD(60 cases) confirmed by the coronary artery angiography.The level of serum APN was measured;the Gensini scores were also evaluated.Results The level of serum APN in those cases has inverse correlation with the Gensini scores(r=-0.639,P<0.05).Conclusion The level of serum APN in the male patients with HBP has significant correlation to the severity of CHD, which may be benefit to clinically evaluate the severity of CHD in male patients with HBP.