糖耐量低减危险因素病例对照研究

Case-control study on the risk factors of impaired glucose tolerance

目的探讨糖耐量低减的危险因素,为制定预防糖耐量低减和Ⅱ型糖尿病的有效措施提供科学依据。方法采用病例对照研究(病例组117人,对照组200人),对导致IGT的危险因素变量进行分析。结果单因素非条件Logistic回归分析显示:年龄(OR=1.506,P=0.004)、饮茶史(OR=1.348,P=0.043)、高血压史(OR=0.417,P=0.003)、冠心病史(OR=2.641,P=0.006)、DM家族史(OR=7.096,P=0.000)、WHR(OR=2.669,P=0.000)、舒张压(OR=2.131,P=0.005)、高血压(OR=1.815,P=0.019)与IGT的发病相关。多因素分析显示:饮茶史(OR=1.372,95%CI 1.006-1.872,P=0.046)、冠心病史(OR=3.176,95%CI 1.535-6.575,P=0.002)、DM家族史(OR=6.460,95%CI 2.525-16.530,P=0.000)和WHR(OR=3.018,95%CI 1.793-5.080,P=0.000)为IGT的危险因素。结论预防IGT的发生及预防IGT向糖尿病的发展将是预防糖尿病最积极的途径。

Objective To discuss the risk factors of impaired glucose tolerance(IGT) to provide scientific base for making some prevention measures of IGT and DMⅡ.Methods Using case-control study(case group,n =117 and control group,n=200) to analyze the variables of the risk factors of IGT.Results Single factor nonconditional logistic regression showed that age(OR=1.506,P=0.004)、history of drinking tea(OR=1.348,P= 0.043)、hypertension history(OR=0.417,P=0.003)、coronary heart disease history(OR=2.641,P=0.006)、family history of DM(OR=7.096,P=0.000)、WHR(OR=2.669,P=0.000)、DBP(OR=2.131,P=0.005)、hypertension(OR=1.815,P=0.019) relate to IGT.Muldtivariable analysis showed that history of drinking tea(OR =1.372,95%CI 1.006-1.872,P=0.046)、coronary heart disease history(OR=3.176,95%CI 1.535-6. 575,P=0.002)、family history of DM(OR=6.460,95%CI 2.525-16.530,P=0.000)、WHR(OR=3.018, 95%CI 1.793-5.080,P=0.000) are the risk factors of IGT.Conclusion The prevention of IGT which may turn to DM will be the most active way of DM prevention.