PAK5在肿瘤组织中的研究进展

Research progress of PAK5 in tumor tissues

PAK5为PAKs(p21活化的激酶)家族中新近发现的成员,PAKs在细胞骨架重组、细胞增殖、细胞侵袭转移、基因转录及细胞凋亡等一系列的细胞功能中发挥着重要的调控作用。PAKs是一类高度保守的丝氨酸/苏氨酸蛋白激酶,通过与Rac和Cdc42结合而激活发挥作用。PAKs作为小G蛋白Rho家族的下游靶蛋白,可被生长因子及其他胞外信号活化。近来研究表明,PAK5在神经源性肿瘤、胃肠癌、骨肉瘤及卵巢上皮癌等过表达。本文就PAK5的结构、表达部位和功能及影响肿瘤细胞增殖、侵袭、转移和凋亡,影响肿瘤耐药的作用等方面综述。

p21-activated kinase 5(PAK5) is a recently identified member of PAKs that play an important role in cytoskeleton remodeling, cell proliferation, cell invasion, gene transcription and cell apoptosis. PAKs are evolutionarily conserved families of serine/threonine protein kinase that are activated by small GTPases of the Cdc42 and Rac families. As the down-stream target protein of Rho family of small GTPase, PAKs can be activated by growth factor and extracellular signaling. Recently, studies found that PAK5 was overexpressed in some cancer such as neurogenic, gastric and colon cancer, osteosarcoma, epithelial ovarian cancer. This review focuses on the structure, expression, function of PAK5, and its role in the proliferation, invasion, apoptosis, and drug resistance of tumor.