药物联合康复训练治疗首发精神分裂症的疗效及其对患者认知功能的影响

Efficacy of drug therapy combined with rehabilitation training in the treatment of first-episode schizophrenia and its effect on cognitive function

目的探讨在药物治疗基础上进行康复训练对首次发作的精神分裂症患者的治疗效果及其对患者认知功能的影响。方法选取于2014年1月1日至2014年12月1日在我院精神卫生中心住院治疗的60例首发精神分裂症患者。利用SAS随机数字软件将其随机分为观察组和对照组各30例,均用非典型抗精神病药物(单一药物)对两组患者进行治疗。观察组在此基础上进行认知康复训练,采用阳性与阴性症状评定量表(PANSS)和威斯康星卡片分类测验-改良版(M-WCST)在治疗前和治疗第3个月对两组患者治疗效果进行评定。结果治疗结束后,观察组PANSS总评分及阴性症状因子分低于对照组,差异均有统计学意义(P<0.05),观察组M-WCST评分错误应答数较对照组低,M-WCST评分总正确应答数和正确分类数高于对照组,WMS短时记忆、瞬时记忆得分高于对照组,差异均有统计学意义(P<0.05)。结论药物治疗联合康复训练对改善首发精神分裂症患者的治疗效果和认知功能优于单一使用药物治疗。

Objective To investigate the clinical efficacy of drug therapy combined with rehabilitation training in the treatment of patients with first-episode schizophrenia and its effect on cognitive function. Methods Sixty patients with first-episode schizophrenia who were treated in the Mental Health Center of our hospital from January 1st,2014 to December 1st, 2014 were selected. The patients was randomly divided into the observation group and the control group using SAS software, with 30 patients in each group. The patients in the control group were treated with atypical antipsychotic drugs, while the patients in the observation group received cognitive rehabilitation training on the basis of the control group. Positive and Negative Symptom Scale(PANSS) and Wisconsin Card Sorting Test(M-WCST)-modified version were used to evaluate the clinical efficacy in the two groups before treatment and after three months of treatment. Results After treatment, the PANSS total score and negative symptom score in the observation group were significantly lower than those in the control group(t=-3.452~4.126, P<0.05). M-WCST score of error responses number in the observation group was significantly lower than that in the control group, and the M-WCST scores of correct responses number and correct classification number in the observation group were significantly higher. WMS short-term memory and episodic memory scores in the observation group were significantly higher than those in the control group(t=-2.354~3.526, P<0.05). Conclusion Drug therapy combined with rehabilitation training is better than single use of drug treatment to improve the clinical efficacy and cognitive function of patients with first-episode schizophrenia.