p38MAPK抑制剂对重症急性胰腺炎的保护

Protection of p38MAPK inhibitor on severe acute pancreatitis

重症急性胰腺炎临床表现凶险,病因复杂,病死率高,是临床常见的急腹症之一,也是临床治疗的难症之一。多种信号通路参与其发生、发展,其中p38MAPK信号转导通路是目前研究的热点。p38MAPK抑制剂是一类合成的小分子有机化合物,其可通过特异性阻断p38MAPK信号转导通路,减少重症急性胰腺炎时炎性介质的表达与释放,减轻器官组织的损伤,有望成为治疗重症急性胰腺炎的有效途径。

Severe acute pancreatitis, one of the most common clinical acute abdominal diseases and one of the difficult diseases in clinical treatment, often happens in emergency with complex etiology and leads to high mortality.Multiple signaling pathways are involved in the pathogenesis and progression of severe acute pancreatitis, in which p38MAPK signal transduction pathway is the most notable. P38MAPK inhibitors, a kind of synthesis of small molecular organic compounds, by their specificity can suppress the expression and release of inflammatory mediators and can relieve the tissues injury. Thus, p38MAPK inhibitors are expected to become the effective way for treatment of severe acute pancreatitis.