miR-137基因rs1625579多态性与精神分裂症发病风险的Meta分析

Correlation between single nucleotide polymorphism rs1625579 in miR-137 gene and schizophrenia: a meta-analysis

目的系统评价mi R-137 rs1625579位点基因多态性与精神分裂症发病风险的关系。方法计算机检索Pub Med、Embase、Springer Link、Wiley Online Library、High Wire Press、Google Scholar和CNKI数据库以获取2015年8月之前发表的关于mi R-137单核苷酸多态位点rs1625579基因多态性与精神分裂症发病的病例对照研究文献,采用Review Manager5.0和Stata12.0统计软件进行统计分析。结果最终纳入8篇,mi R-137基因rs1625579位点多态性与精神分裂症在显性模型(TT+GT vs GG)、隐性模型(TT vs GT+GG)、加性模型(TT vs GG)和等位基因模型(T vs G)分析中差异有统计学意义(P<0.05)。合并OR值分别为1.47、1.21、1.53、1.17;P值分别为0.03、0.001、0.02、0.003。结论 mi R-137单核苷酸多态性位点rs1625579与精神分裂症的易感性均具显著相关,为mi R-137多态性与精神分裂症关联性的研究提供了理论参考。

Objective To assay the association between the single nucleotide polymorphism(rs1625579) in mi R-137 gene and schizophrenia. Methods Studies about the effects of rs1625579 in mi R-137 gene on the sensitivity in patients with schizophrenia until Aug. 2015 were searched from Pub Med, Embase, Springer Link, Wiley Online Library, High Wire Press, Google Scholar, and China National Knowledge Infrastructure(CNKI). Meta-analysis was performed by using Review Manager5.0 and Stata12.0. Results A total of 8 studies were included. A significant association between rs1625579 and schizophrenia was found using dominant [TT+GT vs GG, P=0.03, odds ratio(OR)=1.47], recessive(TT vs GT+GG, P=0.001, OR=1.21), additive(TT vs GG, P=0.02, OR=1.53), and allele(T vs G, P=0.003, OR=1.17) models. Conclusion The results of our study provide convincing evidence that rs1625579 is significantly associated with schizophrenia.