ElastPQ弹性成像技术检测慢性乙型肝炎患者肝硬度的价值

Value of Elast PQ elastography technique in detection of liver stiffness in patients with chronic hepatitis B

目的探索Elast PQ弹性成像技术检测慢性乙型肝炎患者肝硬度的价值。方法选择2014年1月至2015年3月期间慢性乙型肝炎患者54例,根据肝损害程度分为轻度组16例、中度组15例、重度组23例,并选择正常对照组10例,使用Elast PQ弹性成像技术检测其肝硬度,统计分析其差异性。结果 (1)正常对照组肝硬度(5.464±0.176)k Pa,慢性乙型肝炎组肝硬度(9.104±0.678)k Pa,慢性乙型肝炎组肝硬度高于正常对照组,差异有统计学意义(P<0.05);(2)不同程度肝损害组肝硬度分别为轻度组(5.521±0.460)k Pa,中度组(8.660±0.916)k Pa,重度组(11.210±1.135)k Pa。不同程度肝损害组肝硬度比较差异有统计学意义(F=4.946,P<0.05);轻度组分别与中度组和重度组肝硬度比较差异均有统计学意义(P<0.05),而中度组与重度组肝硬度比较差异无统计学意义(P>0.05),且肝功能损害程度越高患者的肝硬度越高。结论 Elast PQ弹性成像技术可以无创定量有效检测肝硬度,为临床治疗慢性乙型肝炎及干预其进展提供了有力的依据。

Objective To explore the application value of Elast PQ elastography technique in detection of liver stiffness in patients with chronic hepatitis B. Methods From January 2014 to March 2015, 54 patients with chronic hepatitis B were selected and divided into three groups according to the degree of hepatic impairment: mild group(16 patients), moderate group(15 patients) and severe group(23 patients). Ten healthy volunteers were selected as normal control group. Elast PQ elastography technique was used to detect the liver stiffness, and statistical analysis on differences and correlation were performed. Results(1) The liver stiffness measurement(LSM) was(9.104±0.678) kpa in patients with chronic hepatitis B, which was significantly higher than that in healthy volunteers of(5.464±0.176) k Pa(P<0.05).(2) The LSM was(5.521±0.460) k Pa in the mild group,(8.660±0.916) k Pa in the moderate group and(11.210±1.135) k Pa in the severe group, with statistically significant difference among the three groups(F=4.946, P<0.05). The difference in LSM was statistically significant between the mild group and the moderate group, severe groups(P<0.05), but not statistically significant between the moderate group and the severe group(P<0.05). The higher the degree of liver damage was, the higher the liver stiffness was. Conclusion Elast PQ elastography technique can be used for noninvasive, quantitative and effective detection of liver stiffness, providing the powerful basis for clinical treatment of chronic hepatitis B and intervention on its progress.