有氧踏车锻炼对H型高血压患者血管内皮功能的影响

Influence of treadmill aerobic exercise on vascular endothelial function in patients with H-type hypertension

目的探讨有氧踏车锻炼对H型高血压患者血管内皮功能的影响。方法选取2014年1~12月在我院就诊的300例H型高血压患者作为研究对象,按随机数表法将其分为有氧踏车锻炼治疗组与常规性治疗组,每组150例,常规性治疗组采用常规性治疗,有氧踏车锻炼治疗组在常规性治疗的基础上进行有氧踏车锻炼治疗,检测两组患者治疗前后一氧化氮(NO)水平、血浆内皮素1水平以及C反应蛋白(CRP)水平,并对结果进行对比分析。结果治疗前,常规治疗组和有氧踏车锻炼治疗组的NO水平分别为(43.52±11.32)μmol/L和(42.96±12.01)μmol/L,治疗后则分别为(56.32±15.38)μmol/L和(68.75±23.21)μmol/L,两组患者治疗后的NO水平均有显著升高,有氧踏车锻炼治疗组比常规性治疗组患者的NO水平在治疗后提高更为显著,差异具有统计学意义(P<0.05);治疗前,常规治疗组和有氧踏车锻炼治疗组的血浆内皮素1水平分别为(90.12±20.31)ng/L和(89.86±19.52)ng/L,治疗后则分别为(73.15±16.54)ng/L和(65.21±12.36)ng/L,两组患者治疗前后的血浆内皮素1水平均有显著降低,有氧踏车锻炼治疗组比常规性治疗组患者的血浆内皮素1水平在治疗后均降低更为显著,差异具有统计学意义(P<0.05);治疗前,常规治疗组和有氧踏车锻炼治疗组的CRP水平为(6.01±1.85)mg/L和(5.99±1.83)mg/L,治疗后则分别为(5.42±1.72)mg/L和(5.39±2.01)mg/L,两组患者治疗前后的CRP水平降低不明显,有氧踏车锻炼治疗组与常规性治疗组患者的CRP含量无明显差异,差异不具有统计学意义(P>0.05)。结论有氧踏车锻炼能够有效地提升H型高血压患者的NO水平,并降低患者血浆内皮素1的含量,进而降低患者血压,达到控制病情的目的,值得广泛推广。

Objective To explore the impact of treadmill aerobic exercise on vascular endothelial function in patients with H-type hypertension. Methods Three hundred patients with H-type hypertension from January 2014 to December 2014 in our hospital were selected as research subjects, which were divided into the study group and the control group by random number table method, with 150 cases in each group. The control group applied conventional treatment, and the study group received aerobic treadmill exercise therapy based on routine treatment.The levels of nitric oxide(NO), plasma endothelin-1 and C-reactive protein(CRP) were detected before and after treatment, and the results were compared between the two groups. Results The NO levels in the control group and the study group after treatment were significantly higher than those before treatment [(56.32 ± 15.38) μ mol/L vs(43.52 ± 11.32) μ mol/L,(68.75 ± 23.21) μ mol/L vs(42.96±12.01) μmol/L, P<0.05), and the improvement in the study group was more significant than that in the control group. The levels of endothelin-1 in the two groups after treatment were significantly lower than those before treatment [(73.15±16.54) ng/L vs(90.12±20.31) ng/L,(65.21±12.36) ng/L vs(89.86±19.52) ng/L], and the decrease in the study group was more significant than that in the control group. The CRP levels in the two groups after treatment showed no statistically significant difference with those before treatment [(5.42±1.72) mg/L vs(6.01±1.85) mg/L,(5.39±2.01) mg/L vs(5.99±1.83) mg/L, P>0.05), and the differences between the two groups were no statistically significant(P>0.05). Conclusion Treadmill aerobic exercise can effectively improve the level of NO in patients with H-type hypertension, reduce plasma level of endothelin-1, and thereby reduce the blood pressure and control the disease, which should be popularized.